One of the current strategies for controlling biofilm involves tailoring the target compounds/drugs to the stages of biofilm formation. For example, efforts to prevent biofilm formation at the initial stage can be undertaken by utilizing inhibitor agents capable of preventing bacterial adhesion to material surfaces. It is anticipated that these inhibitor compounds can disrupt/damage the bacteria's ability to sense the surface intended for colonization. Research on biofilm, particularly in the fields of medicine and health, is currently gaining momentum, not only due to the significant negative impacts biofilm can have on health but also the economic repercussions it generates.